4-Andro rx, also known as 4-DHEA, is a PH to the grand-daddy of all steroids…Testosterone. With an abundance of information available on this essential hormone, I have decided to focus less on the physiological effects of Testosterone itself and instead, have chosen to illuminate the reader on the various potential applications of this legal testosterone elevating agent. In doing so, some may pose the question “why not just use injectable testosterone instead?” Not one to shy away from the tough questions, I will say right up front that when compared directly to testosterone, 4-Andro has its limitations. This is inevitable for a testosterone PH, as all prohormones are limited by their conversion rates to the target hormone. At this stage in the game, no one has yet been able to create a PH which is able to convert to Testosterone in quantities approaching what the typical BB’r might inject. So, for those individuals who have no objection to the use of CIII drugs, by all means, go ahead and use injectable Testosterone; it is the superior choice. However, there is a substantial portion of the population which is opposed to this practice and it is to them that this article is primarily addressed.

In order to accurately evaluate a 4-Andro on a personal level, we must first determine what the individual is trying to accomplish. In the case of this PH, there are multiple potential benefits connected to its administration which are unrelated to muscle growth. One of these is the reversal/prevention of Testosterone deficiency induced side effects. Unfortunately, all steroids (including OTC designers/PHs) lead to suppression of the HPTA, eventually resulting in diminished endogenous Testosterone production. As a consequence, the male body is no longer able to maintain normal physiological functioning and will begin to experience side effects, such as decreased libido, inability to achieve/maintain an erection, a loss of energy/tiredness, depression, impaired cognitive functioning, and a reduced alpha-made mentality, among others. Of course, the growth promoting effects of Testosterone are also lost.

The cure for this predicament is simple. Conventional AAS users can simply inject exogenous testosterone at replacement doses or higher. However, BB’rs who have decided to stick with OTC products as their muscle-building weapons of choice do not have this option. They can either deal with the side effects, or find an alternative. One such option able to effectively meet this need, while also providing additional growth stimulation, is 4-Andro rx. 4-Andro’s lack of methylation makes it an ideal compound for this purpose. Being non-toxic in nature, it is easily stacked with any of the other designers/PHs on the market, providing additional growth and elimination of the above mentioned side effects. This approach is particularly useful for those individuals who like to run cycles longer than 4 weeks, as side effect such as sexual dysfunction are likely to occur beyond that point.

While 4-Andro may do a great job at preventing side effects related to Testosterone deficiency, we should not forget the primary purpose for which this product was produced, namely, to increase lean mass & strength. To this end, at least a little time should be spent addressing the actions of the Testosterone molecule itself, as they pertain to the growth process. Testosterone is properly regarded as being one of the most effective and comprehensive AAS available and for good reason, as it supports muscle hypertrophy through multiple mechanisms. Some of these mechanisms include: Androgen receptor binding, increased androgen receptor concentration, IGF-1 elevation, satellite cell proliferation, and other possible non-genomic mechanisms. Indirectly, Testosterone’s ability to improve growth rate through increased aggression/enhanced alpha-male mind-set is well-noted, with many user claiming to experience improved training sessions when under the influence of elevated testosterone levels. Another well-documented characteristic of androgen administration is its direct effect on nervous system activity; specifically, it improves neural firing, allowing the muscles to contract more forcefully under resistance. This priming of the mind and body enables one to apply greater effort in the gym more easily, further improving one’s overall results.

While we cannot put our finger on an exact conversion rate for 4-Andro rx, user lab-work has revealed Testosterone readings extending well into the supra-physiological range (1,300 ng/dl) 1 week after beginning treatment with the product. This is impressive, given the fact that the molecule must first undergo a 2-step conversion process before being converted into Testosterone. Even with exact ng/dl figures being provided post-administration, it is impossible to extrapolate the increase in testosterone, in terms of mg’s, without a definite baseline. Even so, there are other variables which could impact the final analysis, such as differences in Testosterone metabolism and individual susceptibility to the suppressive effects of 4-Andro. Such discrepancies, even when working with an identical baseline, make it impossible to ascribe an exact mg amount to a particular ng/dl reading.

One advantage of 4-Andro worth mentioning is the product’s ability to increase Testosterone levels without needing to be injected. With all pharmaceutical/blackmarket testosterone products, they must be injected (aside from expensive and marginally effective transdermal preparations) in order to have an effect on the body. Oral consumption is not an option. For those individuals with an aversion to needles, they may find this alternative more appealing. As with all IML products, product testing is mandatory. Each and every batch of raw materials purchased is independently tested through a 3rd party laboratory, confirming product purity & potency. Unlike the numerous companies who offer no such assurance, with IML products, you can be guaranteed that every bottle contains exactly what it says it does.

In conclusion, I find that 4-Andro rx is ideally suited to the following applications. Beginners may find this relatively mild PH an ideal product with which to get their feet wet, although individuals with more experience will likely find it unsuitable for use as a stand-alone product. For those who are using some of IML’s stronger designers or running extended cycles with a combination or methyls & non-methyls, 4-Andro can be used as a stacker, enabling to individual to maintain adequate testosterone levels throughout his cycle and thereby avoiding the sexual dysfunction which often accompanies such cycles.

4-Andro Rx by IronMagLabs:

4-Andro Rx – Buy Here!

Users of Halo For Her™ can expect significant body-recomping effects by implementing this product into their programs, which will be realized through moderate increases in high quality, water-free muscle mass and visible reductions in body fat. Vascularity will be augmented and the user’s muscularity will become harder and denser.

-Comparable to Var
-Helps with Cutting (getting lean)
-Increases Strength & Hardness
-Does Not Aromatize (convert to estrogen)
-Can be used as part of bulking, lean bulking or cutting cycles

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Kudos to Benson, who certainly is one of the Minds on the Mind And Muscle Forums (I don’t know about his muscle, though ;-). Benson dug up a very recent article on the effects of “Ali’s Stick” (Tambi. 2011), which would be the literal translation of “Tongkat ali”, also known as the “Malaysian ginseng”, a herb that has been used by generations of men in South-East-Asia to improve their sexual performance, on testosterone levels in 76 male patients suffering from late-onset hypogonadism (LOH) and, consequently, Aging Males’ Symptoms (AMS).

The study that is going to be published in the next issue of Andrologia, the first international journal of andrology, was conducted by an international team of scientists from Malaysia and South Africa. For their study Tambi et al. recruited a group of initially 350 patients, who were treated at the Wellmen Clinic at Damai Service Hospital in Kuala Lumpur for late-onset hypogonadism (LOD; mean initial testosterone levels: 5.66 nM) and Aging Males’ Symptoms (AMS; mean initial score: 38.05 – higher values = more severe symptoms). The men were treated with 200 mg (two capsules with 100 mg) of a patented, highly standardized water-soluble extract of Tongkat ali (produced by Phytes Bioteks, Biotropics Malaysia, patent number: WO0217946) for 4 weeks, after which both serum testosterone tests, as well as AMS questionnaires were repeated. In the 76 patients who actually completed the trial (cf. discussion of drop out rate at the end of the post)

[...] treatment of LOH patients with this Tongkat ali extract significantly (P < 0.0001) improved the AMS score as well as the serum testosterone concentration. While before treatment only 10.5% of the patients did not show any complaint according to the AMS scale and 35.5% had normal testosterone levels, after the completed treatment 71.7% and 90.8% of the patients showed normal values, respectively.

Quite impressive results for a traditional aphrodisiac. And at first sight, the data on mean, minimal and maximal testosterone levels before and after treatment (figure 1) would corroborate this impression.

Figure 1: Mean, minimal and maximal total testosterone levels of 76 patients with late-onset hypogonadism before and after treatment with 200mg of a patented, standardized Tongkat ali extract for 4 weeks (data adapted from Tambi. 2011)
Unquestionably, Eurycoma Longifolia Jack would make a great addition to the post cycle therapy of drug using athletes and gymrats. Having shut down their natural testosterone production due to the administration of exogenous testosterone or other quasi-hormonal compounds, many steroid users find themselves in a situation of self-inflicted “early-onset” hypogonadism, when they finally come off their steroid cycles. In these circumstances, which closely resemble LOF, “Ali’s stick” may well help to bring the endogenous hormone production back to “normal”.

Figure 2: Illustration of the hormonalproduction line (by Slashme andMikael Häggström; Wikipedia)

Whether the average non-steroid-using gymrat in his early to late twenties would see any benefits does yet remain to be elucidated. Notwithstanding, the results of Ali & Saad from 1993 (unpublished dissertation, cited by Tambi), which suggest that the eurypeptide, the purported active ingredients in the extract, accelarates the hormonal production line at its very beginning, by enhancing CYP17 (17 α-hyroxylase/17, 20 lyase) enzyme activity. Thus boosting “the metabolism of pregnenolone and 17-OH-pregnenolone to yield more dehyroepiandrosterone (DHEA)”, progesterone and 17-OH-progesterone appropriate amounts of the alkaloids, quassinoids, quassinoid diterpenoids, eurycomaosides, eurycolactones, laurycolactones and eurycomalactons from Tongkat ali could eventually facilitate an increase in total testosterone via conversion of the former into 4-androstenedione and testosterone.

It is however more than questionable whether the total testosterone levels of otherwise healthy men would likewise increase by +45%. And even if they did – will you notice the difference? Well, do not expect too much apart from an increase in libido, for we do not know how much of this testosterone is actually free, how the accelaration of the hormonal production line will affect other hormones and binding globolins, etc. Accordingly, you can hope for beneficial effects on athletic performance and/or body composition, yet they are by no means guaranteed – I would not even say “probable”.

All that being said, there is another major drawback that comes with the high dropout-rate of >76% (!) While the scientists don’t comment on the reasons for the dropouts, you may well ask yourself, “Why would a guy who experiences major improvement in the sexual department stop using the very medication that is triggering these improvements?” Well, I guess he would not. So, let’s play devil’s advocate and assume that the testosterone level of the rest of the men did not budge at all (it could well be that due to whatever mechanisms it may even have dropped).

Figure 3: Total testosterone levels before and after treatment for all patients who initiated treatment assuming that that the >75% dropouts did not see any benefits in testosterone (data extrapolated from Tambi. 2011)
In figure 3 I have plotted how the data would like under that assumption. There would still be an increase of 11%, 16% and 20%, for mean, minimal and maximal total testosterone levels, respectively. With a standard deviation of 1.51mM (=27%) and 2.46mM (30%), before and after treatment. Yet, these increases would hardly be significant. You better keep that in mind before you google a source for the patented Tongkat ali extract from Phytes Bioteks (using a non-standardized extract or whole stems, is not likely to work, anyway) and spent your hardly earned bucks into hopes of a jacked physique and animalistic sexual performance. If you insist on trying it, make sure you get enough cholesterol in your diet to feed the process of steroidogenesis (cf. figure 2).

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Article source: http://suppversity.blogspot.com

by John Connor

((2S)-3-(4-cyanophenoxy)-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide)
Imagine a compound that elicits steroid like muscle building effects with little or no androgenic side effects, a compound that packs on lean body mass while lowering body fat in individuals who don’t even weight train, a compound that is safe to use for months and may even be used by females because it does not cause females to develop male sex characteristics, a compound that makes you feel good, improves sleep, increases libido and changes body composition positively. Well, we don’t need to imagine this compound because Osta rx possesses these traits and is a present day reality.

SARM is an abbreviation for Selective Androgen Receptor Modulator. SARMs cause selective anabolic activity in select androgen receptors and not others, hence the term. This nonsteroidal compound has tissue-selective anabolic effects in muscle and bone, while sparing other androgenic tissue related to hair growth in women and prostate effects in men. In other words, SARMs have the potential to offer anabolic effects similar to steroids with little to no common steroidal negative side effects.

SARMs have been studied and developed for over 10 years now by research pharmaceutical company GTx. James Dalton and his colleagues have done numerous studies with hundreds of human participants to determine the viability of SARMs for treating muscle wasting in cancer patients. Typically steroids are prescribed off label to counter muscle wasting diseases but they present several unwanted side effects due to elevations in DHT and Estradiol. Additionally steroids can cause females to develop male characteristics.Therefore a natural need has arisen for an anabolic agent that targets muscle and bone but does not cause other unwanted androgenic activity. SARMs offer an improved benefit to risk ratio for those suffering from muscle wasting.

In August of 2011 a 2006 12-week double-blind, placebo-controlled phase II clinical trial was released to the public absolutely proving that GTx-024 (Ostarine) demonstrated the ability of a nonsteroidal, orally bioavailable SARM to increase lean muscle mass and improve physical function.The conclusion of the study states that;

“There are currently no approved therapies available for the prevention or treatment of muscle wasting. GTx-024 is a novel SARM that was well tolerated in elderly men and postmenopausal women and resulted in significant increases in total lean body mass and improvements in physical function. Importantly, this study provides evidence that GTx-024 provides beneficial anabolic effects on total lean body mass and physical function without the adverse consequences often seen with testosterone and other anabolic steroids. These data support the development of GTx-024 for treatment and prevention of muscle wasting in patients with chronic diseases.”

Furthermore the abstract states that:

“GTx-024 showed a dose-dependent improvement in total lean body mass and physical function and was well tolerated. GTx-024 may be useful in the prevention and/or treatment of muscle wasting associated with cancer and other chronic diseases.”

In other words, the more Ostarine that was administered the greater the increases in lean body mass.

Ostarine and lean body mass

The following chart demonstrates a statistically significant LBM gain of about 3lbs in non-training elderly subjects that were administered a mere 3mg of Ostarine daily for 12 weeks. These subjects also lost almost a pound of body fat at the same time. No differences in total body weight were observed, indicating that the shift to more lean body composition in the 3-mg-dose group was achieved, at least partially, at the expense of body fat.

Fig. 1
Percentage change from baseline to day 86/EOS in total lean body mass: evaluable population. EOS end of study, *P<0.001 3 mg vs. placebo (T test)

Ostarine and power output

The next chart shows that stair climbing power increased dose dependently as well as the decrease in the time needed to climb the stairs.

Fig. 2
Percentage change from baseline to day 86/EOS in stair climb power: evaluable population. EOS end of study, *P=0.0133 mg vs. placebo (T test)

It is important to note that these doses are quite low (3mg or less) and no strength training was performed by the test subjects. Therefore, a subject who administers a higher dose of Ostarine and performs weight resistance training is likely to increase lean body mass by much more while losing body fat.

Ostarine effects on hormones

In men, no statistically significant differences from placebo in change from baseline values for free testosterone, DHT, estradiol, follicle-stimulating hormone (FSH), or LH were observed at any GTx-024 dose. However, sex hormone-binding globulin (SHBG) was significantly reduced with GTx-024 3 mg versus placebo. The decrease in SHBG was accompanied by a reduction of serum total testosterone in subjects treated with 1 mg or 3 mg of GTx-024 compared to placebo. This data demonstrates that Ostarine is total testosterone suppressive but free testosterone, LH and FSH were not statistically suppressed.

Adverse effects

Ostarine did not cause any increase in hair growth or any increase in skin oil. Often times steroids may cause unwanted hair growth and acne but this is not the case with Ostarine. Several participants in the study had temporary elevations in the liver enzyme ALT however those elevations resolved. HDL did lower slightly but the overall cardiovascular risk/benefit ratio for Ostarine is low. Due to these minor temporary negative effects on lipids and ALT liver enzymes, using a cycle supporting supplement and staying properly hydrated are recommended.

Bone Mineral Density

In this 12 week study, Ostarine showed no difference in bone mineral density compared to placebo. Changes in BMD were not necessarily expected as the treatment period was likely too short to detect a benefit. In preclinical studies, Ostarine demonstrated both anabolic and antiresorptive activity in bone. Future research is warranted as the potential dual beneficial effects of Ostarine and other SARMs on muscle and bone may provide a unique advantage to currently available agents for osteoporosis that solely modify bone strength.

Support ingredients in Osta Rx

Osta Rx contains an additional complex of compounds that increase libido in both men and women, mood, sense of well being and energy while improving sleep. Although Ostarine has a half life of 24 hours it is recommended that the doses are split during the day due to these other supporting ingredients.

Dosing for Osta Rx

Osta Rx may be used in male or female users at 3 capsules (20mg Ostarine) per day for up to 8 weeks in duration. Lower doses would allow for longer durations of use.

Osta Rx is an exciting product both on paper and in the real world. Here is a summary of recent user feedback.

* Great pumps
* Leaning out
* Added lean body mass
* Vascularity
* Increased libido
* Improved training recovery
* Strength gains
* No reported side effects
* Little to no suppression
* Improved mood and energy

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References:
The selective androgen receptor modulator GTx-024 (enobosarm) improves lean body mass and physical function in healthy elderly men and postmenopausal women: results of a double-blind, placebo-controlled phase II trial.
http://www.gtxinc.com/Pipeline/OstarineMK2866.aspx?Sid=4

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About the Author:

6-OXO was the 1st effective anti-aromatase to hit the OTC market. Originally formulated and marketed by Patrick Arnold, the chemist-guru who brought pro-hormones to the marketplace, including the original 4AD and 1AD, Patrick was the man who helped launch the modern OTC prohormone movement. Patrick has also been responsible for bringing several undetectable designer steroids to elite athletes, has been featured in bodybuilding magazines as a monthly columnist, owns his own supplement company, and is still widely respected as an authority on anabolic chemistry and ergogenic aids. With that said, we will delve into 6-OXO and explain why it is still relevant today.

So, what are aromatase inhibitors? In Short, they are a category of compounds which reduce estrogen in the body, but in order to have a more thorough understanding of how aromatase inhibitors (which will be referred to as A.I’s from this point forward) work, we will need to define some of the other basic terms associated with the subject of aromatase inhibition. First of all, aromatase is an endogenously produced enzyme responsible for the conversion of testosterone into estrogen. Without aromatase, normal physiological functioning is impaired, as estrogen plays a critical role in the lives of males. However, excess aromatase can result in numerous negative side effects, some of which include increased bodyfat gain, female fat pattern distribution, increased blood pressure, water retention, gynecomastia, reduced libido and sexual functioning, as well as the suppression of both natural testosterone production and spermatogenesis.

While it is possible that elevated levels of estrogen may occur naturally, steroid users are often at a greater risk for experiencing these side effects, due to the use of aromatizable drugs, such as testosterone, Dianabol, etc. When administering a drug such as testosterone in supraphysiological quantities, the body’s natural hormonal environment is disturbed, altering the testosterone to estrogen ratio. In an attempt to correct this imbalance and restore equilibrium, the body’s natural response is too aromatize a portion of the available testosterone into estrogen…and the more testosterone that is present, the more interaction will take place between testosterone and the aromatase enzyme.

This reaction may help to correct the T: E ratio, but it will not do anything to protect the body from the effects of excess estrogen levels. If this weren’t bad enough, users of aromatizable drugs often have to contend with the effects of elevated estrogen post-cycle, resulting in a prolonged recovery of the HPTA. Therefore, management of estrogen both during and post-cycle is critical if the individual wishes to avoid estrogenic side effects and restore testosterone production as quickly as possible.

For those who choose to abide by the law when selecting which A.I. to use while on-cycle and during PCT, the task has become much less arduous, due to recent (and what I believe to be unjustified) government regulation of the supplement market. In an industry which has thrived primarily on hype and deceptive advertising over the years, it is important that the product you select is backed with scientific evidence proving its effectiveness. Otherwise, how will you know it does what is claimed? Fortunately, 6-oxo has amassed an impressive amount of scientific support, as well as demonstrated significant real-world results. In a study conducted at Baylor University, 6-oxo was shown to alter estrogen in favor of testosterone, while simultaneously increasing free testosterone and dihydrotestosterone. See below for a copy of the abstract. The text relaying the study results have been highlighted in blue:

Effects of eight weeks of an alleged aromatase inhibiting nutritional supplement 6-OXO (androst-4-ene-3,6,17-trione) on serum hormone profiles and clinical safety markers in resistance-trained, eugonadal males

Abstract

The purpose of this study was to determine the effects of 6-OXO, a purported nutritional aromatase inhibitor, in a dose dependent manner on body composition, serum hormone levels, and clinical safety markers in resistance trained males. Sixteen males were supplemented with either 300 mg or 600 mg of 6-OXO in a double-blind manner for eight weeks. Blood and urine samples were obtained at weeks 0, 1, 3, 8, and 11 (after a 3-week washout period). Blood samples were analyzed for total testosterone (TT), free testosterone (FT), dihydrotestosterone (DHT), estradiol, estriol, estrone, SHBG, leutinizing hormone (LH), follicle stimulating hormone (FSH), growth hormone (GH), cortisol, FT/estradiol (T/E). Blood and urine were also analyzed for clinical chemistry markers. Data were analyzed with two-way MANOVA. For all of the serum hormones, there were no significant differences between groups (p > 0.05). Compared to baseline, free testosterone underwent overall increases of 90% for 300 mg 6-OXO and 84% for 600 mg, respectively (p < 0.05). DHT underwent significant overall increases (p < 0.05) of 192% and 265% with 300 mg and 600 mg, respectively. T/E increased 53% and 67% for 300 mg and 600 mg 6-OXO, respectively. For estrone, 300 mg produced an overall increase of 22%, whereas 600 mg caused a 52% increase (p < 0.05). Body composition did not change with supplementation (p > 0.05) and clinical safety markers were not adversely affected with ingestion of either supplement dose (p > 0.05). While neither of the 6-OXO dosages appears to have any negative effects on clinical chemistry markers, supplementation at a daily dosage of 300 mg and 600 mg for eight weeks did not completely inhibit aromatase activity, yet significantly increased FT, DHT, and T/E.

Among the various AI’s, they are divided into two different classes, known as Type 1 and Type 2 anti-aromatases. 6-OXO belongs to the Type 1 class of A.I’s, due to its ability to permanently deactivate estrogen at the aromatase enzyme. This is known as suicide inhibition and is a favorable attribute, as it prevents the possibility of experiencing estrogen rebound after cessation of 6-OXO. Other anti-aromatases, such as Exemestane and Formestane, are also suicide inhibitors, while Letrozole and Anastrozole are not.

In addition to the avoidance of estrogen-related side effects, 6-OXO may impart cosmetic benefits, such as an increase in the hardness & dryness of the musculature. This is primarily due to an overall decrease in the body’s level of estrogen–induced water retention and/or a more favorable ratio of androgens to estrogen, allowing the individual to showcase a more visually pleasing physique. 6-OXO also serves as an SHBG modulator, contributing to a further increase in free testosterone. While SHBG (sex hormone binding globulin) is a necessary hormone, it is also directly responsible for making most of the testosterone we produce/administer unavailable for use by the body. It accomplishes this by irreversibly binding to testosterone in the bloodstream, rendering it completely inactive and worthless for muscle-building…or anything else for that matter. In fact, about 98% of all circulating testosterone is bound by this seemingly adversarial protein. Needless to say, a reduction of SHBG is advantageous for those trying to add lean muscle tissue and 6-OXO helps to achieve this.

Whether you are looking to utilize 6-OXO as a part of your post-cycle therapy, to control estrogen while on-cycle, or to improve the visual appearance of your physique, 6-OXO is an effective adjunct to your program.

6-OXO is available from IronMagLabs: E-Control Rx

Click here to view the embedded video.

Click here to view the embedded video.

As many of our previous customers know, Super DMZ was an enormously successful product, containing two of the most popular and effective designer steroids ever produced. This time around IML has gone one step further and brought to market an even more potent product bearing a similar name, known as Super-DMZ Rx 2.0. Super-DMZ Rx 2.0 contains two designer drugs, which are commonly known as Dimethazine and Methylstenbolone.

Users of the original product may be familiar with Dimethazine, as it was one of the two primary compounds responsible for bringing about the dramatic effects Super DMZ was known for. The 2nd molecule included in this potent duo of designer drugs is known as Methylstenbolone. While being less well known, it surpasses Dimethazine in muscle-building capacity, making it the dominant mass & strength compound in this stack.

So, how did Super-DMZ Rx 2.0 come to be and what makes the newest version of the DMZ line so special? Well, with the impending ban of SD soon before us, it made sense to come up with a suitable alternative before SD was pulled off the shelf. We didn’t want to be left with our pants down, so to speak, so we set about looking for SD’s replacement while we still had time. We knew there would be more than few people sad to see SD go…and with good reason, as SD was the most potent designer to hit the market since the banning of M1T in 2004. However, SD’s popularity was attributable to more than just its mass-building potential. Specifically, it was known for stimulating “quality” increases in muscular size, not just wet bulk characteristic of so many other mass-building steroids today. In searching for SD’s replacement, we knew we had to set our sights high. We needed a compound that was not only capable of performing at the same level as SD, but one which could potentially outperform it in terms of muscle growth, while still offering the same high quality gains SD was prized for.

No doubt, this was a tall order and one which not too long ago, would’ve been difficult to fill. Fortunately, due the re-emergence of Methylstenbolone, which was first synthesized decades ago in an American laboratory, we knew we had found our player. Let’s take a closer look at some of Methylstenbolone’s defining characteristics, in order to familiarize ourselves with what is destined to become the next great OTC designer.

In 1966 M-Sten (short for Methylstenbolone) was researched by Searle Laboratories, along with several other compounds; several of which have become well known in the OTC designer steroid world. Some of the steroids included in this research were Desoxymethyltestosterone (Pheraplex), Methyl-1-Testosterone (M1T), and 17a-methyl-1-androstenediol (M1-Alpha). At the conclusion of this research, the results were compared against several other well known steroids, all of which are still regularly used today. The results of this comparison were shocking, with the researchers commenting that “Even the least active compound in Table 6 (see below) possessed a higher relative myotropic (muscle-building) potency than had previously been obtained with several clinically interesting compounds, which have been studied under identical conditions, such as Oxymetholone (Anadrol), Oxandrolone (Anavar), Stanozolol (Winstrol), and Methandrostenolone (Dianabol).”

Even a novice in the world of steroids understands that Anadrol and Dianabol are considered “strong” steroids. In fact, Anadrol was long believed by many to be the most potent oral steroid in the world when it came to adding overall muscle mass. For every single steroid studied in Table 6 (below) to be considered more myotropic than Anadrol (aside from methyltestosterone), we are indeed looking at a powerful class of compounds.

As you can see by the chart above, M-Sten (highlighted in red) is over 2/3rd as myotropic as the insanely powerful M1T, per mg. In comparison, Superdrol’s anabolic rating is about 400, making M-Sten over 1/3rd more potent than SD. While a drug’s anabolic rating doesn’t always directly correlate with its ability to induce size & strength gains (think Anavar), if we use other drugs in this class as a guidepost for what kind of results to expect relative to their myotropic rating, M-Sten can be expected to deliver great gains in size & strength. Fortunately, we do not have to guess when it comes to this steroid’s muscle building potential, as real-world results provide us with clear answers. In terms of lean tissue, M-Sten ranks right up there at the top of the heap, likely providing greater gains per mg than not only every other OTC designer currently on the market, but also every prescription steroid which is available through a pharmaceutical company.

Structurally, M-Sten is an amalgamation between SD & M1T, sharing significant characteristics of both. However, in terms of visual results, M-Sten will more closely resemble Superdrol, providing the user with a hard, dense, and dry appearance to his muscularity. When it comes to strength enhancement, M-Sten will perform impressively, rivaling steroids such as Superdrol and Anadrol. Certainly, this is a drug strength athletes will be able to put to good use. In accordance with other DHT derivatives, M-Sten also lacks the ability to aromatize to any degree, nor is it capable of 5a-reduction.

Like all methylated steroids, M-Sten will exhibit some degree of liver toxicity, but when used responsibly, this should remain a non-issue. When discussing hair loss, it should be remembered that the likelihood of experiencing this side effect is largely based on the individual’s genetic predisposition. Still, M-Sten does not seem to be particularly prone to causing this side effect, being much less likely than Testosterone or Trenbolone to initiate hair loss. Overall, the uses for which this steroid finds itself suitable are numerous. It can be used effectively in off-seasons BB’rs, pre-contest competitors, or strength athletes all with good effect.

The 2nd anabolic agent in this stack, Dimethazine, is no slouch in the muscle growth department itself. In fact, according to the university research shown below, Dimethazine was shown to deliver greater muscle-building results than Winstrol, Testosterone propionate, Methyltestosterone, and even Anadrol, on a mg to mg basis.

Biological activity of Dimethazine in the protein-anabolic field.

Matscher, R.; Lupo, C.; De, P. Ruggieri. Lab. Ric. Ormonoter. Richter, Milan, Bollettino – Societa Italiana di Biologia Sperimentale (1962), 38 988-90. CODEN: BSIBAC ISSN: 0037-8771. Journal language unavailable. CAN 58:34623 AN 1963:34623 CAPLUS

Abstract

“Dimethazine (I), 2,17-dimethyl-5-androstan-17-ol-3,3′-azine, was compared to methyltestosterone, oxymethalone, androstanazole and testosterone propionate in its protein-anabolic activity. The tests were made on castrated rats with a single hypodermic injection of 250 , on young male and female rats with increasing daily oral doses from 100 to 1000 for 30 days, and on adult male rats with daily oral doses of 1000 for 25 days. It was shown that I did not interfere with the growth of young animals; that adult rats treated with I gained, on an av., 20 g. more in wt. than the controls; and that I had a greater myotropic effect on castrates than the other steroids, and induced a higher N retention than methyltestosterone in adult males.”

Most people are not aware of just how strong this compound is, but most people understand that when a steroid surpasses Anadrol in terms of growth potential, we are dealing with one bad-ass drug…and Dimethazine is no exception. In terms of both structure and effect, Dimethazine is amazingly similar to SD. Technically, Dimethazine is simply two SD molecules held together by an azine bond. Once the compound is ingested, the bond is severed, liberating free SD and releasing it into the bloodstream to interact with the androgen receptor. This makes Dimethazine a non-aromatizing, non-progestagenic, methylated oral steroid, which exhibits a reduced degree of liver toxicity in comparison to SD.

Super-DMZ Rx 2.0 should not be underestimated nor should dosing recommendations be exceeded. With the arrival of Super-DMZ Rx 2.0, IronMagLabs has brought to market the highest dosed version of Methylstenbolone yet. As usual, IML doesn’t cut corners by offering under-dosed products designed only to spare profits, which occurs so frequently with other companies. This formulation will provide a full 10 mg of Methylstenbolone and 10 mg of Dimethazine per cap! To put this in perspective, the next-closest competitor doses their Methylstenbolone product at only 4 mg per cap and contains no additional compounds. For the 1st time, consumers will be provided with the opportunity to take full advantage of Methylstenbolone since its release onto the marketplace. Just like with the original Super DMZ, 1-2 caps per day is all that is required in order to witness extreme changes in one’s physique and strength levels. If you liked Super DMZ, you will love Super-DMZ Rx 2.0!

With most oral AAS, the best mass & strength builders are almost always accompanied by varying degrees of water retention and/or significant androgenic side effects. When it comes to Super-DMZ Rx 2.0, not only does it provide superior growth potential and rival or surpass the best strength builders on the market (legal or otherwise), but it does so while making you drier, harder, denser, and more vascular at the same time. In addition, it is less likely to cause oily skin, acne, hair loss, or other androgenic side effects when comparing it to steroids of similar potency.

With Super-DMZ Rx 2.0, visually stunning results combine with massive strength increases to make it the most impressive product on the market. After using just a single bottle, we are confident you will agree wholeheartedly. Not one to be outperformed, IML went above and beyond in the formulation of this product because we understand that our customers want and deserve only the best.

You know the old expression when Life gives you lemons you make lemonade? So when something bad happens you do what you can to make the best of it right? Well I’m at a pretty rough crossroads now…life has certainly tossed me some lemons and its up to me to get this lemonade made. How will I? That is yet to be determined but I will break down whats going on. Last saturday, as in 9 days ago I was looking the best I have ever looked 3 weeks before a show.

I will include a couple random pics I took that morning right when I woke up in trunks to show you. No pump, just woke up and snapped some pics. I was 232.8 lbs ever so close to the elusive 225 I have been fighting for and very confident that in 3 weeks I would be there, and be my best ever by far. I wanted the judges at USA to be really impressed with my condition and I was on pace for that to happen. The following Monday I did what for lack of a better description was a DUMB LEG WORKOUT. I mean I just really over did it, but I was in a zone and I just wanted to go with it! Most seriously lifters have had those days! The next day I felt completely wiped out, it was the worst I have ever felt before a show. I could barely get out of bed…I had to do my AM cardio at only 2.5 mph and my legs felt like cement. The whole day I was really out of it and I wanted to just get the day over with ever so bad! The next day, Wed, I was feeling a bit better ,thank god, so I got up and took a more aggressive approach to my cardio. Banged out 45 min and was feeling good. Came home to make my breakfast, ate it and went to take a shower because I had a chiropractor appointment.

Here is where the Lemons start…about an hour after breakfast I start feeling this odd pain in my stomach. I thought perhaps it was some kind of indigestion so I popped a couple TUMS and jumped in my car. On my way to the Chiro my pain in my abdomen got so intense that I had to pull the car over. I sat there for a few min and it wouldn’t go away. At this point I was kinda scared because I have a freakish pain tolerance( its actually been a curse over the years) and for me to feel like this was not a good sign. I called my girlfriend and told her I was going home to get in bed. Thankfully my girlfriend came home from work scared and got me up. She said we are going to the DR now! I didn’t want to go, I hate going to the Dr and I really hate hospitals. I started researching what could have been wrong with me and all the symptoms were pointing to pretty serious conditions so I decided she was right, lets get to the doctor.

I went to the walk in clinic here in my current town of San Clemente and it didn’t take the DR all but 2 min to say you need to go to the Emergency room immediately your gal bladder is under great stress! This was what I was afraid of…the dreaded hospital. By the time I got to the emergency room I could barely fill out the paper work but they got me in a room and with a DR surprisingly fast! They got me on and IV and hooked me up with a painkiller called dilauded that took my pain from a 9 to a 1 in a matter of min. The Dr came in and said they wanted to do an ultra sound of my gal bladder because he believed I was having gal stones…made sense to me but whats odd is I eat a very low fat diet….Blood drawn, ultra sound performed and the Dr comes back and says, “OK, so there is nothing wrong with your gal bladder and all your blood work looks great but your liver enzymes are elevated” I said all bodybuilders have elevated liver enzymes… He decided that we needed to do a cat scan of my abdomen. The cat scan revealed an interesting “lemon”.

Im laying in the bed and the Dr comes in and says “well you have a 3cm mass in your liver that could possibly be a simple cyst or it could be a tumor, we really don’t know and we need to do more tests, I want to keep you here over nite.” I was pretty freaked out hearing that and my girlfriends eyes welled up at the news, but I looked at her and said, “I just have a really strong feeling its not a tumor babe, don’t worry about me”. Staying in the hospital sucked!! I actually had my laptop so I could stay on top pf my work and manage my clients from bed, lol. My nurses at nite were ok, and the Dr who came in to talk with me was a complete moron who was basically google searching things on his iPhone saying dumb shit like” what kind of testosterone do you take?THe patch? Uou know that can cause cancer right?” Thankfully I only so that numb nuts for 5 min.

The next day I woke up and waited for hours to see anyone. It was particularly annoying because they were not allowing me to eat or drink anything and I was already dead tired and hungry from all this contest prep, I just waned some frigging tliapia or something, lol.

Finally around 2 in the afternoon a 3rd Dr came in and said we want to do another Cat scan in 2 weeks…what I believe you had happen was a liver hemangioma that ruptured and if that was the case you will heal pretty fast a long as you don’t do any heavy lifting and rest for a couple weeks….So a much better prognosis then a tumor that would need a biopsy! I said, “DR I have been training for almost 2 years for this show in in 14 days…can I compete. I don’t have to lift “heavy”" his response was “well if I tell you I don’t think its a good idea will you be upset? I said to him, “I want you to tell me I will die if I try to compete. otherwise I’m not quitting.” He smiled and said you won’t die but you can potentially slow your recovery or make yourself worse, just be very careful and listen to your body.

So fast forward to me getting home from the Hospital…not only am I in terrible pain but I step on the scale 243 bloated lbs…the IV they had me hooked up too was pumping me full of salt…that was frustrating…I felt I lost a whole week not to mention I was in horrible pain and can’t even take a single advil because it can cause my liver to bleed more slowing the recovery.

Today is now Monday just inside of two weeks from the USA. My pain level is the same. I can barely get around, but I have managed some VERY light workouts for my circulation and have stayed on my diet. Im sure a lot of people would just say F it,give me some ice cream at this point, but I just wanna stay positive and hope I can pull through to this show. I want this show so bad. At this point I realize I am not going to look how I expected too…however maybe if done right, I can still look my best because of where I was at before…and I think it will be a testament to my will if I can can see this through. There is no shame in pulling out or holding off but I wanna try.

I received a call from IFBB Pro Dr Victor Prisk who is a friend of mine, a great bodybuilder, a judge and a frigging MD! He was strongly against me doing USA and even said if you want go make a public statement saying Dr Prisk said I can not do the USA! I respect him and his friendship as well as his brain of course but I told him I was going to take it day by day. I also got a call from Derek Anthony who, love him or hate him has always been really cool to me over the years. he had gone through something similar in 2007 and told me he was hospitalized for 6 days and I should expect to be in pain for about 10. Awesome, another LEMON!!!

What am I gonna do with all these Lemons folks?? Its going to be a hell of a glass of lemonade thats for sure! As of right now I am dieting and wondering over to my treadmill for some slow and mild cardio…diet is still on point. weight is back down where it should be, I actually still look good…pain is still hi. Day by day…I know what I want to happen…l guess time will tell.

Ask PJ any questions you want here: Q & A with PJ Braun NPC National Bodybuilder Competitor

Super-DMZ Rx 2.0 is an over the counter legal product that contains 10mg of Methylstenbolone and 10mg of Dimethazine per capsule. Dimethazine is two steroid molecules bound together by a nitrogen atom. Upon ingestion, stomach acid separates the two steroid molecules that closely resemble methyldrostanolone (Superdrol). Methylstenbolone shares similar characteristics of Superdrol and M1T and would be considered just as strong as either of these more well-known compounds. Therefore Super DMZ 2.0 contains two very strong compounds that will rival almost any designer or traditional steroid on the market today in terms of strength, power and lean body mass gains.

Dimethazine was a prescribed steroid at one time therefore we have human trials in which this steroid was used. This medication has been around since 1962 when it was presented in the literature. Early on it was sold under the Roxilon brand name. Dimethazine is basically an oral Masterone (drostanolone propionate). Published reports indicate that Dimethazine possesses an androgenic rating of 96 and an anabolic rating of 210. Furthermore it seems to possess little to no estrogenic or progestational activity. One of the reasons I feel this is not identical to Superdrol is because Superdrol has a different androgenic/anabolic rating of 20/400 respectively. However Dimethazine is a strong steroid on its own. The addition of Methylstenbolone makes Super DMZ rx 2.0 an even stronger designer steroid.

Methylstenbolone possesses an androgenic rating of 170 and a whopping anabolic rating of 660. Research dating back to the mid 1960′s proves that Methylstenbolone has a greater muscle building effect than Anadrol or Dianabol. Methylstenbolone is an active and orally-bioavailable DHT-derived compound that resists metabolic breakdown. As a result, Methylstenbolone has a long acting pharmacokinetic profile and exceptional potency. It does not aromatize into any estrogenic compound and has no affinity for the progesterone receptor, so estrogen and progesterone receptor mediated side effects are unlikely.

Dimethazine is an oral c-17alpha alkylated steroid that is liver toxic to a degree. Note that in studies administering 20mg daily to female patients for 45-95 days, dimethazine was shown to induce modest to moderate bilirubinemia (excess bilirubin in the blood, indicative of hepatic stress) in close to 50% of patients. Approximately 25% of the patients noticed substantial increases inserum transaminases. These results suggest this steroid has some hepatoxicity and should therefore be limited to shorter durations of use. Methylstenbolone is also known for hepatoxicity so care must be taken when using Super DMZ rx 2.0.

Super DMZ 2.0 is a very potent oral steroid that should illicit solid gains in lean body mass with little water or fat gain depending on nutritional intake. Most users can tolerate between 20-40 mg (1-2 capsules) daily for 4-6 weeks however more adventuresome users may use up to 60mg (3 capsules) daily for shorter durations like 2-3 weeks. What’s most striking about this designer steroid is how rapid and dry LBM gains can be achieved in such a short time frame. SDMZ 2.0 reminds me of a faster acting, dryer, high dosed Dianabol or Anadrol. However SDMZ rx 2.0 is much stronger mg for mg than Dianabol or Anadrol. Users of SDMZ 2.0 can expect to add 10-15lbs of lean body mass in about 4 weeks of administration with proper diet and training. Super DMZ rx 2.0 is a very strong, clean designer steroid that can be used to increase lean mass, strength and power with little to no water retention in short periods of time.

Lipid and Organ Support

Because of the liver toxicity of Super DMZ rx 2.0 I strongly recommend using liver supporting supplements such as IronMagLabs Advanced Cycle Support and/or Liv 52 before and during administration of this designer steroid. Proper hydration is also recommended to lower stress on organs. Alcohol and other liver stressing medications like acetaminophen should be avoided during Super DMZ 2.0 administration. Oral steroids often times negatively affect lipids therefore lipid supporting supplements should also be employed such as omega 3 fish oils, fiber and plant sterols. High blood pressure is another concern so that should be monitored regularly. Consult your health care professional before using any dietary supplements.

Post Cycle Therapy

Since Super DMZ rx 2.0 will cause interruption of the Hypothalamic-Pituitary-TesticularAxis, post cycle therapy is strongly recommended. Bulbine natalensis or ProLensis is an amazing over the counter testosterone recovery supplement. It stimulates the production of GNRH and also increases cholesterol in the testes. Prolensis causes production of LH, which in turn signals the testis to produce testosterone. Evidence shows that ProLensis can stimulate LH 169% compared to study controls. Research further shows Testosterone is boosted a whopping 347%! This natural compound is a main ingredient in IronMagLabs Ultra Male Rx. Ultra Male Rx also has pro sexual effects as well as boosting Testosterone. Some Testosterone boosting compounds may increase Estrogen but in rodent studies it was confirmed that the main ingredient in Ultra Male Rx actually decreases Estrogen by 35%.Ultra Male Rx is a legal way to significantly boost testosterone, control Estrogen and raise libido.

Sample Cycle

Weeks 1-4 Super DMZ RX 2.0~2 capsules per day
Weeks 1-8 Advanced Cycle Support~2 capsules per day (organ and lipid support)
Weeks 5-8 Ultra Male RX~1 capsule per day (Post Cycle Therapy) A SERM may also be used as PCT.

Super-DMZ rx 2.0 is currently available for purchase without a prescription. IronMagLabs Super-DMZ Rx 2.0

Chemical Name(s): Dimethazine
17beta-hydroxy 2alpha,17alpha-dimethyl 5alpha-androstan 3-one azine

Chemical Name(s): Methylstenbolone
2,17α-dimethyl-5α-androsta-1-en-17β-ol-3-one, or 2,17a-Dimethyl-17b-hydroxy-5a-androst-1-en-3-one

Referrences:

1. Biological activity of dimethazine in the protein-anabolic field.
2. Protracted action of protein anabolism in gynecological oncology and its effect on hepatic function.
3. A new steroid with protein anabolic activity: dimethazine. 
4. Biological determination of the secondary hormonal activities of dimethazine. 
5. Antigonadotropic action of a new steroid with anabolizing activity studied in the anterior pituitary gland of the castrated rat 
6. Methylstenbolone Explained
7. Anabolic and androgenic activities of Bulbine natalensis stem in male Wistar rats
8. Effect of aqueous extract of Bulbine natalensis (Baker) stem on the sexual behaviour of male rats.

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