The anti-diabetes effect of Green Coffee Bean
In May 2020, we wrote about a meta-study, which showed that supplementation with Green Coffee Bean extract causes modest but significant weight loss. The same researchers published a new meta-study in Nutrition Journal, which suggests that Green Coffee Bean extract may also be an interesting supplement for people looking to lower their glucose and insulin levels.Study

The researchers collected 14 previously published trials involving a total of 766 subjects. The doses ranged from 90 to 6000 milligrams of extract per day. The duration of the trials varied from 2 to 16 weeks.The main active ingredient in Green Coffee Bean extract is chlorogenic acid, a phenol that allows more glucose to be absorbed by activating AMPK muscle cells. This may be because chlorogenic acid inhibits enzymes such as glucose-6-phosphatase, thereby reducing the conversion of amino acids into glucogen.

Green Coffee Bean reduced the amount of glucose in the blood - more precisely: the fasting blood glucose level. In addition, there was a trend that Green Coffee Bean lowered insulin levels. The effect was not excessive, but still.

In the trials, the amount of chlorogenic acid ranged from 13.5 to 1200 milligrams per day.
In the figure below, the researchers looked at the relationship between the dose of chlorogenic acid and the drop in glucose levels. The optimal dose appears to be close to 500 milligrams.

Nutr J. 2020 Jul 14;19(1):71.