Glucosamine sulfate and Chondroitin sulfate are components of normal cartilage. They are the building blocks for proteoglycans and stimulate chondrocytes to make new collagen and proteoglycans. Because these supplements stimulate the production of new cartilage components, the supplements may be able to help the body repair damaged cartilage. There is evidence from patients that Glucosamine and Chondroitin can reduce pain from osteoarthritis, usually within several weeks to months after initiating therapy. MSM has shown benefits for a range of health problems including arthritis, muscle and joint pain. MSM has shown promise in the inhibition of pain impulses along nerve fibers, (analgesia), lessening of inflammation, increasing blood supply, reducing muscle spasms, and softening of scar tissue.
Flex Rx™ Ingredients Explained
Glucosamine: occurs naturally in the body. It helps make cartilage stronger and more rigid. Glucosamine supplements typically are made from a protein found in the shells of shrimp, crab and other shell fish. Some research shows that glucosamine supplements relieve pain in some people with osteoarthritis (OA) of the knee. Osteoarthritis, also called degenerative joint disease, is the most common type of arthritis. It is associated with a breakdown of cartilage in joints and commonly occurs in the hips, knees and spine. It also often affects the finger joints, the joint at the base of the thumb, and the joint at the base of the big toe.
Chondroitin: enhances the shock-absorbing properties of collagen and block enzymes that break down cartilage. Studies are being done to evaluate the ability of chondroitin to reverse cartilage loss. It generally takes two to four months to work completely. Two large studies that evaluated data from about a dozen studies showed significant improvement in pain and inflammation and improved joint function. Some people taking Chondroitin are able to decrease NSAID dosage.
Methylsulfonylmethane (MSM): is a naturally occurring sulfur compound containing sulfur and methyl groups. It is found in the normal diets of humans and almost all other animals. MSM is made up of 34% sulfur, the fourth most abundant mineral in the human body. MSM has shown benefits for a range of health problems including arthritis, muscle and joint pain. MSM has shown promise in the inhibition of pain impulses along nerve fibers, (analgesia), lessening of inflammation, increasing blood supply, reducing muscle spasms, and softening of scar tissue. MSM supports healthy, active lifestyles and benefits multiple structures and functions within the body, including connective tissues and the respiratory system while the methyl groups support energy production.
The Science of Glucosamine and Chondroitin
Physical Effects on Knee Osteoarthritis
There are a number of quality clinical studies on humans that demonstrate glucosamine sulfate is effective as a treatment for mild to moderate knee osteoarthritis. PubMed cites a 2002 long-term study from the Czech Republic that concluded glucosamine sulfate retarded progression of knee osteoarthritis, reduced pain and increased flexibility.
Physical Effects on Arthritic Pain
Glucosamine sulfate with and without chondroitin sulfate has demonstrated the ability to relieve arthritic pain. A quality example is noted again by PubMed, which cites a 2007 study reported in “Arthritis Rheumatology” that concluded glucosamine sulfate is more effective than acetaminophen in treating the symptoms of knee osteoarthritis. This study, along with most that show positive physical effects, used 1,500mg of glucosamine sulfate daily.
Physical Effects of Chondroitin on Knee & Hip Pain
Although chondroitin is often combined with glucosamine in supplements and in clinical studies, it has shown beneficial physical effects by itself. The University of Maryland Medical Center has concluded that several scientific studies suggest that chondroitin sulfate may be effective for symptomatic relief of knee and hip osteoarthritis but not necessarily for cartilage repair or new growth. The typical dosage of chondroitin sulfate in clinical trials is 1,200 mg daily.
Glucosamine & Chondroitin Combined
A large, multi-center trial in the U.S. begun in 1998, called GAIT, tested whether glucosamine and chondroitin used separately or in combination reduced pain in participants with knee osteoarthritis. The results were that both glucosamine and chondroitin showed positive results separately, as did the glucosamine/chondroitin combo, but the combination did not show additional “synergistic” benefits. It was noted in this large trial that significant clinical changes from glucosamine and chondroitin can take up to three months to be noted.
Take five (5) capsules once daily with food and water.
Do not exceed the recommended dose. This product should not be used by anyone under the age of 21. Do no use if pregnant or nursing, or if you are at risk of, or being treated for diabetes or high blood pressure. Consult your health care professional before using any dietary supplements.