You will see results if your diet and exercise routine are on point. However it is my understanding that at about 5 weeks in the true benefits can be seen, such as better vascularity, improved strength and lean mass gains. Also it seems that Osta has a great thermogenic property....meaning it burns fat while you build muscle! I am personally 3 weeks in so all I can tell you is it has benefits so far for me in the mass gain department. As for needing to run anything else the answer is no....it is not necessary, during or after. Unless you want to stack it with a PH or any of the new andro products for improved results. I guess you could stack it with ultra male as well if you wanted to. It is a very versatile supplement.