GUARANTEED ABSORPTION. NO NEEDLES, NO PILLS, NO LIVER STRESS!†
Prohormones – Topical vs. Oral Administration
Although comparable to oral-dosage forms in efficacy, topical creams have numerous advantages over oral forms. First, topical administration avoids the first-pass effect of metabolism associated with the oral route. Therefore, topical administration allows for much higher and improved bioavailability. Second, topical administration allows prolonged release of prohormone compounds, which can improve adherence. Third, topical administration minimizes adverse effects due to lower prohormone peak concentrations. Prohormones are very effectively removed by the liver when taken orally. This means that much higher doses, ten to twenty times higher, must be taken when administering prohormones orally, as compared to topical administration that avoid the first pass effect of the liver.†
(Per 2 Pumps)
- 75mg Nor-DHEA
- 75mg 7-Keto DHEA
- 50mg 5-DHEA
- 100 Pumps Per Bottle
- Suggested Dose is 2 Pumps Daily
Nor-DHEA is the prohormone of choice for many people looking to improve their overall lean muscle mass and is safe for females due to its very low androgenic (male characteristics) activity.†
7-Keto-DHEA is a prohormone produced by metabolism of the prohormone dehydroepiandrosterone (DHEA). 7-keto-DHEA helps speed up the metabolism and heat production to promote weight loss. It also helps to improve lean body mass and build muscle, increase the activity of the thyroid gland, boost the immune system, enhance memory, and slow aging.†
Clinical Research for 7-Keto DHEA
A randomized, double-blind, placebo-controlled study of 3-acetyl-7-Keto-dehydroepiandrosterone in healthy overweight adults
The purpose of this study was to determine the effects of 3-acetyl-7-Keto-dehydroepiandrosterone (7-Keto DHEA) in healthy overweight adults.
In a double-blind, placebo-controlled protocol, 30 adults (28 women and 2 men; mean age, 44.5 ± 11.5 years) with a mean body mass index of 31.9 ± 6.2 kg/m2 were randomly divided into 2 groups of 15: Group 1 received 7-oxo-DHEA 100 mg twice daily and Group 2 received placebo for 8 weeks. All subjects participated in an exercise training program 3 times per week. Each exercise session consisted of 60 minutes of cross-training (aerobic and anaerobic exercise) under the supervision of an exercise physiologist. In addition, each subject was instructed to follow a diet of ~1800 kcal/d (20 kcal/[kg · d]) by a registered dietitian. Subjects received biweekly dietary counseling to encourage compliance. Study participants underwent serum multiple-assay chemistry testing, as well as body composition, blood pressure, and dietary analysis at baseline, week 4, and week 8.
Of the 30 subjects who entered the study, 23 completed the 8-week protocol. Seven subjects dropped out for personal reasons unrelated to the study. Group 1 lost a significant amount of body weight compared with Group 2 (−2.88 kg vs −0.97 kg; P = 0.01) over the 8 weeks. Group 1 also achieved a significant reduction in body fat compared with Group 2 (−1.8% vs −0.57%; P = 0.02). The rate of change in body fat per 4-week interval in Group 1 was 3.1 times that in Group 2 (−0.88% vs −0.28%; P < 0.01). Group 1 also experienced a significant increase in triiodothyronine (T3) levels compared with Group 2 over the 8-week study period (+17.88 ng/dL vs 2.75 ng/dL; P = 0.04). There were no significant changes in levels of thyroid-stimulating hormone (TSH) or thyroxine (T4) in either group. In addition, no significant changes were observed in vital signs, blood sugar, testosterone and estradiol levels, liver and renal function, or overall caloric intake during the study. No subjective adverse effects were reported throughout the study.
The results of the study suggest that 7-Keto DHEA combined with moderate exercise and a reduced-calorie diet significantly reduces body weight and body fat compared with exercise and a reduced-calorie diet alone. In addition, 7-Keto DHEA significantly elevated T3 levels but did not affect TSH or T4 levels, indicating that it does not adversely affect thyroid function in the short term.
5-DHEA has been popular in the life extension crowd since the 1980’s. It’s typically used for its ability to support energy and general well being. More recently higher doses of 5-DHEA have been used to improve body composition due to DHEA’s mild anabolic and thermogenic effects. This makes 5-DHEA an excellent choice for cutting during a calorie deficient diet since 5-DHEA has good muscle sparing properties.†
Lean AF Topical Delivery System
- Dimethyl Isosorbide (DMI) – is a high purity solvent and carrier which offers a safe, effective delivery enhancement mechanism for the active ingredients in Lean AF.
- Ethoxydiglycol – is a cosmetic grade solvent that conforms to the current USP/NF monographs. Ethoxydiglycol is particularly appropriate for skin care preparations where it acts as an excellent solvent and carrier.
- Propylene glycol – is an organic compound that is used 2 primary reasons. First, it has the traits of a humectant; it is able to absorb and help the skin retain moisture. Second, it helps active ingredients penetrate the skin.
- Glycerin – when used on skin works as humectant, which is why it attracts moisture onto your skin.
- Carbomer – helps to distribute and suspend the active ingredients in the Lean AF.
- Triethanolamine (TEA) – Helps the water-soluble and oil-soluble ingredients blend better. TEA neutralizes fatty acids and solubilizes oils and other ingredients that are not completely soluble in water.
For best results apply 1 pump of LEAN AF Cream twice daily (1 pump in AM & 1 pump in PM) to the upper arms, shoulders/traps, thighs or abdominal areas. Ensure the areas are clean and free from excessive hair, avoid showering or swimming for at least 8 hours after application.